HBT: Indians cut loose Sizemore, keep Carmona

Fausto Carmona will stay with Cleveland in 2012 after the team exercised his $7 million option, but the Indians made Grady Sizemore a free agent by choosing a $500,000 buyout rather than pay him $8.5 million following another injury wrecked season.

Once upon a time Sizemore was one of the best young players in baseball and the Indians? biggest long-term building block, but he hasn?t been productive since 2009 and hasn?t been healthy and productive since 2008.

During the past two seasons he?s missed 220 of a possible 324 games while hitting just .220 with a .659 OPS and knee injuries cast some doubt on his ability to be an asset in center field at age 29. I?ll be interesting to see if any teams are willing to risk offering him more than a one-year deal, because had Sizemore been a free agent a few years ago $100 million offers would?ve piled up.

Carmona failed to build on a strong 2010, going 7-15 with a 5.25 ERA in 32 starts, but the Indians aren?t ready to cut ties with the 28-year-old right-hander and he?d likely have had little trouble securing a multi-year deal on the open market.

Source: http://hardballtalk.nbcsports.com/2011/10/31/indians-bring-back-fausto-carmona-cut-loose-grady-sizemore/related/

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UFC 137 picks, Vegas-style: Iole and Cofield give out their winners

UFC 137 betting odds:

MAIN CARD (Pay-per-view)

Nick Diaz (+110) vs. B.J. Penn (-130) - Welterweight

Cheick Kongo (+120) vs. Matt Mitrione (-140) - Heavyweight

Mirko "Cro Cop" Filipovic (+235) vs. Roy Nelson (-275) - Heavyweight

Hatsu Hioki (-335) vs. George Roop (+275) - Featherweight

Jeff Curran (+325) vs. Scott Jorgensen (-450) - Featherweight

PRELIMINARY CARD (Spike TV)

Donald Cerrone (-245) vs. Dennis Siver (+205) - Lightweight

Tyson Griffin (-320) vs. Bart Palaszewski (+260) - Featherweight

PRELIMINARY CARD (Facebook)

Eliot Marshall (+310) vs. Brandon Vera (-370) - Light heavyweight

Danny Downes (+175) vs. Ramsey Nijem (-210) - Lightweight

Chris Camozzi (-135) vs. Francis Carmont (+115) - Middleweight

Dustin Jacoby (-125) vs. Clifford Starks (-105)- Middleweight

Watch UFC 137 right here on Yahoo! Sports

Source: http://sports.yahoo.com/mma/blog/cagewriter/post/UFC-137-picks-Vegas-style-Iole-and-Cofield-giv?urn=mma-wp8658

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"Wild Cards" superhero anthology to get movie treatment (Reuters)

NEW YORK (TheWrap.com) ? George R.R. Martin, the author behind HBO's "Game of Thrones," has sold another one of his projects to Hollywood.

SyFy Films, a theatrical division run under the auspices of NBC Universal, has purchased the movie rights to "Wild Cards," a superhero anthology edited by Martin.

The anthology of 22 books dates back to 1987 and depicts a world in which an alien virus has been unleashed in New York, killing almost everyone put in contact with it.

Of the survivors, most have been rendered deformed while a few have gained superpowers.

This is the first acquisition for SyFy Films, which launched in December 2010.

"Wild Cards presents a terrific franchise opportunity given the volume of material from this compelling fantasy series," Gregory Noveck, VP of Production at SyFy Film, said in a statement. "We're thrilled to have the opportunity to develop a film based on the anthology's supernatural heroes, and to be working with such talented and visionary writers as George R.R. Martin and Melissa Snodgrass."

"Wild Cards" was created by a group of science fiction authors, but Martin took a leadership role in editing it and contributing. Melinda Snodgrass, who will write the script, has also been a contributor to the series, which is still producing new volumes thanks to the efforts of a bevy of writers.

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/nm/20111028/film_nm/us_wildcards

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Obama lost many donors from '08 presidential race (AP)

WASHINGTON ? President Barack Obama has lost millions of dollars in support from former donors in Democratic strongholds and in districts that he won narrowly four years ago, according to an Associated Press analysis of the most recent federal campaign finance data.

Tens of thousands of supporters who gave him hundreds of dollars or more in the early stages of the 2008 campaign haven't offered him similar amounts of cash so far in this campaign. And in some cases, former Obama contributors gave to GOP candidates, such as former Massachusetts Gov. Mitt Romney.

Obama's re-election effort is hardly hurting for cash: His campaign and the Democratic Party raised more than $70 million for Obama's re-election in the July-September period, outstripping all Republicans combined by tens of millions of dollars.

But the AP's analysis indicates that Obama, beleaguered by a struggling economy, has lost early support from some of his larger financial supporters and will have to work harder to win back party stalwarts and swing voters alike. Obama's approval ratings have slumped to 41 percent in a recent Gallup poll, as steadfast supporters have found themselves less able or less willing to open their wallets again.

"He was our state senator, and when I looked at the Republican side, I thought, `We need some fresh blood in the campaign,'" said Janet Tavakoli, 58, a financial analyst from Chicago who gave $1,000 to the president in 2008. "But I was dead wrong about it," she said, and isn't supporting any candidate this time.

Obama faced then-Sen. Hillary Rodham Clinton for the Democratic nomination in 2008. This time he is running unchallenged and has no primaries or caucuses looming, as the Republican candidates do, so potential Obama donors may not be feeling any sense of urgency. But typically early donors tend to give again, as money is a sign of enthusiasm ? something Obama had in spades four years ago.

For its analysis, the AP compared the names and addresses of Obama contributors who gave between $200 and $2,500 from April to September 2007 with those who gave amounts in the same range during the same period this year. The AP adjusted its analysis to compensate for contributors who might have moved and listed a new address, or whose name or address was listed slightly differently last time.

The Obama campaign said most of its contributors gave small donations this year; it is not required under federal law to provide names of donors who gave less than $200. About 40 percent of total fundraising came from amounts greater than $200 this year, not adjusting for inflation, compared with more than 75 percent during the same period in 2007.

Obama's missing contributors live across the country, mostly concentrated in the Northeast and the West Coast. Obama also missed support from early donors in parts of Texas, Illinois and Michigan ? areas he narrowly won in 2008. But he also picked up some new sources of cash in those places.

"I have little discretionary money, and I just have to take care of myself," said Roger Hodges, 45, an urban designer in Richmond, Calif. Hodges gave Obama $250 four years ago but doesn't plan on donating in this election. Hodges said friends in the liberal-leaning San Francisco Bay Area have become disappointed in Obama.

Romney, a leading GOP contender, has closed in financially in areas of the country that gave a solid stream of checks to Obama in the 2008 campaign, including Southern California, Florida and New England. Records show a handful of Obama contributors from 2008 donated to Romney this time; few, if any, appeared to give to Texas Gov. Rick Perry, another front-runner.

Lynda Marren, 48, of Hillsdale, Calif., usually supports Republican politicians, but she paid $500 to hear Obama speak four years ago.

"I wasn't persuaded then, and still am not," she said, and gave $1,000 to Romney this past June.

Many Obama supporters said they will vote for his re-election even if they don't write big checks. About 4 out of 5 of those who voted for the president in 2008 say they are likely to do so again, according to a new NBC News/Wall Street Journal poll.

But Obama's contributions this recent fundraising quarter ? absent support from the Democratic National Committee ? are less than the combined cash given to all GOP candidates, hinting at an influx of money to whomever Republicans chose as their nominee. Observers have said this election likely will cost more than $1 billion.

The Obama campaign, for its part, said more than a million people have given to the president's 2012 re-election efforts, a mix of hundreds of thousands of new and returning donors that spokesman Ben LaBolt said points to "evidence of a growing organization." All told, Obama received donations from a wide swath of the United States from the Plains, the Midwest and parts of the South since April, the AP's analysis found.

Among those donors was Laurel Cappa of Washington, who gave $300 to the president four years ago and opened her wallet again this year.

"It was a birthday gift to myself," she said, having turned 70 this year, "and I expect to be giving more."

The campaign reports offer a complicated financial picture for Obama this election cycle. Recent reports show a mixed level of financial support from Wall Street, and an AP analysis earlier this month found Obama garnered continued donations from the nation's most economically hard-hit areas.

The campaign figures, however, didn't capture money raised by new, outside groups known as super political action committees, which can collect unlimited amounts of cash to influence elections. Obama and leading GOP candidates all have super PACs working in their favor, not counting groups like the GOP-leaning American Crossroads that have raised hundreds of millions ahead of the general election.

___

Follow Jack Gillum at http://twitter.com/jackgillum

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20111028/ap_on_el_pr/us_obama_s_missing_donors

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Cell phone warnings blocked in San Francisco: judge (Reuters)

(Reuters) ? A U.S. judge blocked most of a San Francisco ordinance on Thursday that required warnings about cell phone safety risks, saying it violated the First Amendment.

Health questions about cell phone use grew this year after a group of World Health Organization cancer experts suggested that such use be deemed "possibly carcinogenic." Industry groups say this does not mean that cell phones cause cancer.

Among the ordinance's provisions is one requiring retailers to display large posters stating in bold that "studies continue to assess potential health effects of mobile phone use."

In his ruling, U.S. District Judge William Alsup said it was acceptable that customers be given "fact sheets" to discuss possible risks of cell phone use, but insisted on changes to the current sheets so they do not mislead customers into believing that cell phones are dangerous.

The judge disallowed provisions of the ordinance that mandate large posters and warning stickers on in-store displays.

The city will ask a federal appeals court to uphold part of the ruling which allows the fact sheet to go forward, San Francisco City Attorney Dennis Herrera said in a statement.

However, Herrera said he will also ask the appeals court to make clear the city has even broader authority.

"I disagree with his decision to limit the city's message in the way he has done," Herrera said of Alsup's ruling.

John Walls, VP of public affairs for wireless industry group CTIA, said the organization was considering its options.

"CTIA respectfully disagrees with the court's determination that the city could compel distribution of the revised 'fact sheet,'" Walls said in a statement.

Alsup ruled that most of the ordinance violated the U.S. Constitution. San Francisco may "within reason" force retailers to communicate its message, Alsup wrote, but "cannot paste its municipal message over the message of the retailers."

Alsup temporarily blocked enforcement of the ordinance through November 30 pending expected appeals, and said he will void it entirely if the city refuses to revise the fact sheets.

The case in U.S. District Court, Northern District of California is CTIA-The Wireless Association v. The City and County of San Francisco, California, 10-cv-3224.

(Reporting by Dan Levine in San Francisco and Jon Stempel in New York, editing by Bernard Orr)

Source: http://us.rd.yahoo.com/dailynews/rss/personaltech/*http%3A//news.yahoo.com/s/nm/20111028/us_nm/us_cellphones_sf_ruling

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Python study may have implications for human heart health

Thursday, October 27, 2011

A surprising new University of Colorado Boulder study shows that huge amounts of fatty acids circulating in the bloodstreams of feeding pythons promote healthy heart growth, results that may have implications for treating human heart disease.

CU-Boulder Professor Leslie Leinwand and her research team found the amount of triglycerides -- the main constituent of natural fats and oils -- in the blood of Burmese pythons one day after eating increased by more than fifty-fold. Despite the massive amount of fatty acids in the python bloodstream there was no evidence of fat deposition in the heart, and the researchers also saw an increase in the activity of a key enzyme known to protect the heart from damage.

After identifying the chemical make-up of blood plasma in fed pythons, the CU-Boulder researchers injected fasting pythons with either "fed python" blood plasma or a reconstituted fatty acid mixture they developed to mimic such plasma. In both cases, the pythons showed increased heart growth and indicators of cardiac health. The team took the experiments a step further by injecting mice with either fed python plasma or the fatty acid mixture, with the same results.

"We found that a combination of fatty acids can induce beneficial heart growth in living organisms," said CU-Boulder postdoctoral researcher Cecilia Riquelme, first author on the Science paper. "Now we are trying to understand the molecular mechanisms behind the process in hopes that the results might lead to new therapies to improve heart disease conditions in humans."

The paper is being published in the Oct. 28 issue of the journal Science. In addition to Leinwand and Riquelme, the authors include CU postdoctoral researcher Brooke Harrison, CU graduate student Jason Magida, CU undergraduate Christopher Wall, Hiberna Corp. researcher Thomas Marr and University of Alabama Tuscaloosa Professor Stephen Secor.

Previous studies have shown that the hearts of Burmese pythons can grow in mass by 40 percent within 24 to 72 hours after a large meal, and that metabolism immediately after swallowing prey can shoot up by forty-fold. As big around as telephone poles, adult Burmese pythons can swallow prey as large as deer, have been known to reach a length of 27 feet and are able to fast for up to a year with few ill effects.

There are good and bad types of heart growth, said Leinwand, who is an expert in genetic heart diseases including hypertrophic cardiomyopathy, the leading cause of sudden death in young athletes. While cardiac diseases can cause human heart muscle to thicken and decrease the size of heart chambers and heart function because the organ is working harder to pump blood, heart enlargement from exercise is beneficial.

"Well-conditioned athletes like Olympic swimmer Michael Phelps and cyclist Lance Armstrong have huge hearts," said Leinwand, a professor in the molecular, cellular and developmental biology department and chief scientific officer of CU's Biofrontiers Institute. "But there are many people who are unable to exercise because of existing heart disease, so it would be nice to develop some kind of a treatment to promote the beneficial growth of heart cells."

Riquelme said once the CU team confirmed that something in the blood plasma of pythons was inducing positive cardiac growth, they began looking for the right "signal" by analyzing proteins, lipids, nucleic acids and peptides present in the fed plasma. The team used a technique known as gas chromatography to analyze both fasted and fed python plasma blood, eventually identifying a highly complex composition of circulating fatty acids with distinct patterns of abundance over the course of the digestive process.

In the mouse experiments led by Harrison, the animals were hooked up to "mini-pumps" that delivered low doses of the fatty acid mixture over a period of a week. Not only did the mouse hearts show significant growth in the major part of the heart that pumps blood, the heart muscle cell size increased, there was no increase in heart fibrosis -- which makes the heart muscle more stiff and can be a sign of disease -- and there were no alterations in the liver or in the skeletal muscles, he said.

"It was remarkable that the fatty acids identified in the plasma-fed pythons could actually stimulate healthy heart growth in mice," said Harrison. The team also tested the fed python plasma and the fatty acid mixture on cultured rat heart cells, with the same positive results, Harrison said.

The CU-led team also identified the activation of signaling pathways in the cells of fed python plasma, which serve as traffic lights of sorts, said Leinwand. "We are trying to understand how to make those signals tell individual heart cells whether they are going down a road that has pathological consequences, like disease, or beneficial consequences, like exercise," she said.

The prey of Burmese pythons can be up to 100 percent of the constricting snake's body mass, said Leinwand, who holds a Marsico Endowed Chair of Excellence at CU-Boulder. "When a python eats, something extraordinary happens. Its metabolism increases by more than forty-fold and the size of its organs increase significantly in mass by building new tissue, which is broken back down during the digestion process."

The three key fatty acids in the fed python plasma turned out to be myristic acid, palmitic acid and palmitoleic acid. The enzyme that showed increased activity in the python hearts during feeding episodes, known as superoxide dismutase, is a well-known "cardio-protective" enzyme in many organisms, including humans, said Leinwand.

The new Science study grew out of a project Leinwand began in 2006 when she was named a Howard Hughes Medical Institute Professor and awarded a four-year, $1 million undergraduate education grant from the Chevy Chase, Md.-based institute. As part of the award Leinwand initiated the Python Project, an undergraduate laboratory research program designed to focus on the heart biology of constricting snakes like pythons thought to have relevance to human disease.

Undergraduates contributed substantially to the underpinnings of the new python study both by their genetic studies and by caring for the lab pythons, said Leinwand. While scientists know a great deal about the genomes of standard lab animal models like fruit flies, worms and mice, relatively little was known about pythons. "We have had to do a lot of difficult groundwork using molecular genetics tools in order to undertake this research," said Leinwand.

CU-Boulder already had a laboratory snake facility in place, which contributed to the success of the project, she said.

"The fact that the python study involved faculty, postdoctoral researchers, a graduate student and an undergraduate, Christopher Wall, shows the project was a team effort," said Leinwand. "Chris is a good example of how the University of Colorado provides an incredible educational research environment for undergraduates." Wall is now a graduate student at the University of California, San Diego.

###

University of Colorado at Boulder: http://www.colorado.edu/news

Thanks to University of Colorado at Boulder for this article.

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Source: http://www.labspaces.net/114699/Python_study_may_have_implications_for_human_heart_health

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FCC shifts subsidy fund to broadband (Reuters)

WASHINGTON (Reuters) ? Regulators agreed on Thursday to change an $8 billion national communications subsidy program to put more emphasis on providing high-speed Internet access to rural areas.

The Federal Communications Commission voted unanimously to shift roughly $4.5 billion spent annually to subsidize rural telephone service over to providing broadband in rural and costly-to-serve areas.

Broadband buildout to unserved areas could begin in early 2012 under the plan, helping bring high-speed Internet to the 18 million Americans who have no access to broadband where they live and work.

"We are taking a system designed for the Alexander Graham Bell era of rotary telephones and modernizing it for the era of Steve Jobs and the Internet future he imagined," FCC Chairman Julius Genachowski said at the agency's open meeting.

The revised universal service program would phase out funding for landline phone service over a period of years as companies move to a competitive bidding process for securing funds for broadband.

Companies now receiving phone service subsidies -- paid for through fees added to consumers' telephone bills -- would get first rights in some areas to receive support for deploying broadband service.

The new rules would also eliminate spending on duplicative services offered by several phone companies serving the same area.

As part of the changes, regulators are tweaking the complex system of payments among carriers to complete connections called intercarrier compensation, gradually reducing per-minute intercarrier compensation charges.

Incumbent phone carriers would be able to mitigate losses from reduced intercarrier revenues through a new access recovery charge on landline service.

The FCC put a $0.50 limit on the annual increase in the monthly charge, which could reach up to $2.50 per month after five years.

"The Commission did take steps to narrow the scope of these rate increases, but asking consumers to pay more into a broken system and letting the industry divvy up the pot will not increase broadband adoption," said Joel Kelsey, political advisor for public interest group Free Press.

FCC staff said they expect the charge to be closer to $0.10 to $0.15 per month as carriers must demonstrate an equivalent revenue loss from the reduction in intercarrier compensation rates.

Genachowski told a news conference after the FCC meeting that he expected consumer rates to fair better under the reforms than if the current system stayed in place.

"It's not a close call. The consumer benefits from the reforms today are massive, very significant," he said.

He added that hidden subsidies and a lack of oversight on the fund's size would have translated directly into increases on consumers' local phone bills had they gone unchecked.

The new Connect America Fund will have a firm $4.5 billion a year budget through 2017, the first budget constraint ever imposed on the universal service program.

Up to $2 billion would be available for small carriers serving mostly rural areas, $1.8 billion for large and mid-sized carriers like AT&T Inc, Verizon Communications and CenturyLink, and $500 million for mobile broadband.

(Reporting by Jasmin Melvin; Editing by Tim Dobbyn)

Source: http://us.rd.yahoo.com/dailynews/rss/internet/*http%3A//news.yahoo.com/s/nm/20111027/wr_nm/us_fcc_usf_reform

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NYC man pleads guilty to kidney trafficking (AP)

TRENTON, N.J. ? A New York man pleaded guilty Thursday to what experts said was the first ever proven case of black-market organ trafficking in the United States.

Levy Izhak Rosenbaum admitted in federal court in Trenton that he had brokered three illegal kidney transplants for New Jersey-based customers in exchange for payments of $120,000 or more. He also pleaded guilty to one count of conspiracy to broker an illegal kidney sale.

His attorneys, Ronald Kleinberg and Richard Finkel, said in a statement that their client had performed a life-saving service for desperately ill people who had been languishing on official transplant waiting lists.

"The transplants were successful and the donors and recipients are now leading full and healthy lives," the statement said. "In fact, because of the transplants and for the first time in many years, the recipients are no longer burdened by the medical and substantial health dangers associated with dialysis and kidney failure."

The lawyers added that Rosenbaum had never solicited clients, but that recipients had sought him out, and that the donors he arranged to give up kidneys were fully aware of what they were doing. The money involved, they argued, was for expenses associated with the procedures, which they claim were performed in prestigious American hospitals by experienced surgeons and transplant experts. The lawyers did not name the hospitals involved, nor are they named in court documents.

Prosecutors argued that Rosenbaum was fully aware he was running an illicit and profitable operation ? buying organs from vulnerable people in Israel for $10,000, and selling them to desperate, wealthy American patients.

"A black market in human organs is not only a grave threat to public health, it reserves lifesaving treatment for those who can best afford it at the expense of those who cannot," said New Jersey's U.S. Attorney, Paul Fishman. "We will not tolerate such an affront to human dignity."

Each of the four counts carries a maximum five-year prison sentence plus a fine of up to $250,000. Rosenbaum also agreed to forfeit $420,000 in real or personal property that was derived from the illegal kidney sales.

The 60-year-old Rosenbaum is a member of the Orthodox Jewish community in the Borough Park section of Brooklyn, where he had told neighbors he was in the construction business.

He was arrested in July 2009 in a sweeping federal case that became the largest corruption sting in New Jersey history. Though he was one of more than 40 people arrested, including politicians and rabbis in New Jersey and Brooklyn, and was not a rabbi himself, the image of rabbis illegally selling kidneys garnered international headlines and made its way into the routines of late-night comedians for weeks afterward.

Rosenbaum was arrested after he tried to set up a kidney sale to a man posing as a crooked businessman but who actually was government informant Solomon Dwek, a disgraced real estate speculator facing prison time for a $50 million bank fraud.

Dwek, wearing a wire for federal investigators, brought Rosenbaum an undercover FBI agent posing as his secretary, who claimed to be searching for a kidney for a sick uncle on dialysis who was on a transplant list at a Philadelphia hospital.

"I am what you call a matchmaker," Rosenbaum said in a secretly recorded conversation. "I bring a guy (who) I believe, he's suitable for your uncle."

Asked how many organs he had brokered, he said: "Quite a lot," the most recent two weeks earlier.

For someone who was not a surgeon, Rosenbaum seemed in his recorded conversations to have a thorough knowledge of the ins and outs of kidney donations, including how to fool hospitals into believing the donor was acting solely out of compassion for a friend or loved one.

He was recorded saying that money had to be spread around liberally, to Israeli doctors, visa preparers and those who cared for the organ donors in this country. "One of the reasons it's so expensive is because you have to shmear (pay others) all the time," he was quoted as saying.

"So far, I've never had a failure," he bragged on tape. "I'm doing this a long time."

At a 2008 meeting with the undercover agent, Rosenbaum claimed he had an associate who worked for an insurance company in Brooklyn who could take the recipient's blood samples, store them on dry ice and send them to Israel, where they would be tested to see if they matched the prospective donor, authorities said. Donors would then be brought from Israel and undergo surgery to remove the kidney in a U.S. hospital, according to court documents.

Although the hospitals where the operations Rosenbaum arranged have not been named, critics and experts on organ trafficking say many U.S. hospitals do not have vigorous enough procedures for looking into the source of the organs they transplant because such operations are lucrative.

Despite guidelines from various groups and Medicare, U.S. transplant centers are mostly free to write their own rules for screening donors to make sure they are not selling their organs. The questions they ask vary widely. Some hospitals require long waiting periods to weed out shady donors; others don't.

Under 1984 federal law, it is illegal for anyone to knowingly buy or sell organs for transplant. The practice is illegal just about everywhere else in the world, too.

But demand for kidneys far outstrips the supply, with 4,540 people dying in the U.S. last year while waiting for a kidney, according to the United Network for Organ Sharing. As a result, there is a thriving black market for kidneys around the world.

Art Caplan, the director of the Center for Bioethics at the University of Pennsylvania and a co-chairman of a United Nations task force on organ trafficking, said kidneys are the most common of all trafficked organs because they can be harvested from live donors, unlike other organs. He said Rosenbaum had pleaded guilty to one of the "most heinous crimes against another human being."

"Internationally, about one quarter of all kidneys appear to be trafficked," Caplan said. "But until this case, it had not been a crime recognized as reaching the United States."

___

Porter reported from Newark.

___

Follow Samantha Henry at http://www.twitter.com/SamanthaHenry.

Source: http://us.rd.yahoo.com/dailynews/rss/health/*http%3A//news.yahoo.com/s/ap/20111027/ap_on_re_us/us_black_market_kidneys

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Oil spill claims czar: Shrimpers' pain continues (AP)

The administrator of the $20 billion fund set up to compensate individuals and businesses hurt by last year's Gulf of Mexico oil spill said Thursday new rules are being formulated to make payouts more generous for hard-hit shrimpers.

Washington attorney Kenneth Feinberg told a House Committee on Natural Resources hearing he hopes to announce the rules within two weeks.

He agreed with concerns from shrimpers that the length and extent of damage they have suffered because of the April 2010 disaster has been more significant than first thought.

"I think we've got to do better for the shrimpers," Feinberg said.

Feinberg remains under fire for the slow pace of payments and for denying many claims. Eighteen months after the spill, the fund has paid $5.5 billion to 213,408 claimants. More than 300,000 other claimants have been denied compensation. Feinberg agreed in July to a Justice Department audit. He said at the hearing the audit hasn't started. Justice officials didn't immediately respond to a request for comment.

The committee chairman, Rep. Doc Hastings, R-Wash., said that despite assurances from the White House following the oil spill that BP would be held fully accountable "that does not appear to be the case." He said the number of people paid to date, considering how many have applied for money, is "simply unacceptable."

Rep. Edward Markey of Massachusetts, the ranking Democrat on the committee and a frequent critic of BP, offered support for BP's efforts with regard to compensating victims through the fund.

"Here I believe the company did the right thing," Markey said. He said "the fund kept families and businesses afloat."

An Associated Press review published in February that included interviews with legal experts, government officials and more than 300 Gulf residents found a process beset by red tape and delay, and at the center of it all a fund administrator whose ties to BP have raised questions about his independence.

Critics say little has improved since then, and in some cases has gotten worse.

Many observers worry a big chunk of the $20 billion will be returned to BP when the Gulf Coast Claims Facility ceases making payouts, which is currently scheduled for August 2013. At one point, Feinberg told reporters that he expected half of the fund to be sufficient to compensate all victims. He took considerable heat for making that prediction, and he has declined to speculate on the issue in the months since then.

"The $20 billion was supposed to be the floor, not the ceiling," Rep. Steven Palazzo, R-Miss., told Feinberg at Thursday's hearing.

Eleven rig workers were killed when the Deepwater Horizon exploded roughly 50 miles off Louisiana while the crew was working to temporarily abandon an undersea well drilled by oil giant BP PLC. According to government estimates, some 206 million gallons of oil spewed from BP's Macondo well, making it the largest offshore oil spill in U.S. history. BP owned the well and was leasing the rig from Transocean Ltd.

BP is preparing to drill a new well in 6,000 feet of water in the Gulf ? deeper than at Macondo ? some 246 miles south of Lafayette, La., after receiving the go-ahead from the U.S. government on Wednesday. It's the first such permit BP has received since the oil spill.

The semisubmersible drilling rig West Sirius, owned by Norwegian offshore drilling firm Seadrill Ltd., is already at the site. BP says it will start drilling "as soon as operationally possible."

___

Follow Harry R. Weber at http://www.facebook.com/HarryRWeberAP

Source: http://us.rd.yahoo.com/dailynews/rss/environment/*http%3A//news.yahoo.com/s/ap/20111027/ap_on_re_us/us_gulf_oil_spill_claims

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Steven Tyler falls in bathroom, taken to hospital

ASUNCION?? Steven Tyler, the lead singer of rock band Aerosmith, had a "small accident" on Tuesday that forced him to postpone a planned show in Paraguay by one day, a spokesman for the local concert organizers said.

Tyler received stitches and had emergency dental work done during a nearly four-hour stay at the La Costa medical center in Paraguay's capital, according to a hospital statement. He was in good condition when discharged.

The 63-year-old frontman reportedly suffered cuts to his face and lost two of his teeth after falling in his hotel bathroom, the country's largest newspaper ABC said.

Aerosmith planned to perform in the South American nation of Paraguay on Tuesday during a tour through Latin America.

"Mr. Tyler had a small accident that prevents him from staging the concert tonight," Marcelo Antunez, a spokesman for the local concert organizers, told reporters.

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   5. 'Jurassic Park' has one of scariest scenes ever

"He is fine, he's in his hotel but he's not able to do the concert," Antunez said, adding the show would be postponed until Wednesday.

Nicolas Garzia, whose firm organized the Paraguay gig, said via Twitter that Tyler had been dehydrated and was suffering gastrointestinal problems.

A man who identified himself as Gustavo Perez, a bellboy at the Bourbon hotel near Asuncion, told local radio that Tyler slipped when he was taking a shower and "had a nasty fall."

Two years ago, Tyler broke his shoulder after falling off the stage during a concert in South Dakota, forcing the group to scrap the rest of its North American tour that summer and aggravating tensions within the band.

Tyler has signed up for a second season as a judge on the singing talent show "American Idol," and he published a memoir this year called "Does this Noise in My Head Bother You?"

Copyright 2011 Thomson Reuters. Click for restrictions.

Source: http://today.msnbc.msn.com/id/45037757/ns/today-entertainment/

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Why So Many Crashes of Bee-Carrying Trucks?

Well, a bee weighs between 90 and 180mg [answers.com], I'll just assume 100mg on average. That makes for a combined weight of 25M*0.1g = 2.5Mg = 2.5t

When all 25 million bees take of, they reduce the lorry's weight by 2.5 tonnes? Whoa.

But wait! The lorry is closed at the bottom,/me guesses. Air cant escape downward (maybe to the sides or upward?). -- So, no.
No change in weight after all, as the downward pressure from their wings should equal their mass as they hover around

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/VSI8Z7nWwzA/why-so-many-crashes-of-bee-carrying-trucks

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Review: `Like Crazy' a glum, mopey romance (AP)

The doomed romance "Like Crazy" creates an increasing sense of tension, a tightening in your gut. It makes you squirm in your seat ? not because the angst of the young love depicted on screen is so vivid and relatable, but because these two people are so incredibly annoying together, you'd much rather see them apart.

Actually, the scenes in which Anton Yelchin and Felicity Jones are living separate lives in different cities ? on different continents with an ocean dividing them ? make more sense. Sure, they had their fun, but clearly it's not going to work, so it's time to move on. Live and learn. Sunrise, sunset.

But no, this is supposed to be a cosmic first love that transcends all reason, so writer-director Drake Doremus keeps shoving them back together, keeps finding strained ways for their lives to intertwine.

Yelchin and Jones do have some chemistry early on, though, in the halcyon glow of their blossoming relationship. He plays Jacob, a Los Angeles college student. She plays Anna, a British classmate of his who's here on a student visa. They fall hard and fast and in no time they're reciting poetry and making scrapbooks and furniture for each other. It's all very gooey and emo.

But then, the morning Anna is supposed to fly back to London because her visa has run out, she decides she'll just stay. She knows she's supposed to return, if only for a couple of months, but that's too long for her and Jacob to be apart. They're young and in love ? the rules shouldn't apply! So she sticks around for one more blissful summer, with some serious consequences.

From here, "Like Crazy" traces the various text messages and terse conversations, missed connections and misplaced anger that plague these two as they try to navigate the complicated immigration system. Their exchanges frequently turn pouty and mopey for no good reason; it's no fun to be in that kind of relationship yourself, but watching two other people behave this way is even more agonizing.

And it all might have been vaguely poignant if the reason for their estrangement weren't so avoidable. All Anna had to do was get on a plane, miss her boyfriend for a couple of months, and then return safely and happily. Either she's a) too stupid to recognize the danger of her actions or b) too much of a selfish, impetuous child to care, but whatever the answer, it's hard to root for her and for them to reunite ultimately.

During one of their many breakup periods, they start dating other people, which is actually preferable. After graduation and once he's launched a furniture design company in his industrial downtown loft, Jacob gets involved with the young woman who works for him played by Jennifer Lawrence (who also happened to play his girlfriend earlier this year in "The Beaver"). And right then and there it's like: movie's over. He could either date this beautiful, smart, cool girl who just happens to live in the same city, or he can pine for some glum, passive-aggressive chick eight time zones away who peeks at his cellphone during the rare times when they are together. The answer seems clear.

"Like Crazy" was a favorite at this year's Sundance Film Festival, winning the dramatic grand jury prize as well as a special award for Jones' performance. I find that warm reception baffling. And lest you assume that I'm cold and crusty and don't remember what it's like to fall in love, I wrote this review on my 14th wedding anniversary.

"Like Crazy," a Paramount Pictures release, is rated PG-13 for sexual content and brief strong language. Running time: 89 minutes. One and a half stars out of four.

___

Motion Picture Association of America rating definitions:

G ? General audiences. All ages admitted.

PG ? Parental guidance suggested. Some material may not be suitable for children.

PG-13 ? Special parental guidance strongly suggested for children under 13. Some material may be inappropriate for young children.

R ? Restricted. Under 17 requires accompanying parent or adult guardian.

NC-17 ? No one under 17 admitted.

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/ap/20111026/ap_en_mo/us_film_review_like_crazy

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Can You Be Scared Enough To Pee Your Pants?

There?s a related condition known as paruresis, or shy bladder. Sufferers find it nearly impossible to urinate in the presence of others. The neurological basis for the disorder is very poorly understood, but it seems to be the neurological opposite of what happened to the target of NASA sting. The inhibitory signal from the prefrontal cortex becomes hyperactive, for some reason. You might think of paruresis as the story of civilization run slightly amok. The brainstem acts on a primordial level, controlling our most basic behaviors. The prefrontal cortex evolved inhibitory centers to control impulses. Without it, we would urinate and defecate freely, and violate all manner of social norms. The importance of these inhibitory centers can be seen in patients with Alzheimer's, stroke victims, and those who have suffered catastrophic brain injuries. Oftentimes, they lose control over their excretory habits.

Source: http://feeds.slate.com/click.phdo?i=c254b528998a8df5a8b16c99559dd299

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Writer Isaacson on Steve Jobs: 'I just listened'

This undated photo made available by his publicist on Wednesday, Oct. 26, 2011 shows author Walter Isaacson. Steve Jobs told Isaacson he wanted him to write his biography because he's good at getting people to talk. Jobs, it turns out, didn't need much prodding, secretive as he was about both his private life and the company he founded. "I just listened," said Isaacson, whose book, "Steve Jobs" went on sale Monday, Oct. 24, 2011. Jobs, who died Oct. 5 at the age of 56 after a long struggle with pancreatic cancer, was a man full of deep contradictions, a product of 1960s counterculture who went on to found what is now the world's most valuable technology company, Apple Inc. (AP Photo/Patrice Gilbert)

This undated photo made available by his publicist on Wednesday, Oct. 26, 2011 shows author Walter Isaacson. Steve Jobs told Isaacson he wanted him to write his biography because he's good at getting people to talk. Jobs, it turns out, didn't need much prodding, secretive as he was about both his private life and the company he founded. "I just listened," said Isaacson, whose book, "Steve Jobs" went on sale Monday, Oct. 24, 2011. Jobs, who died Oct. 5 at the age of 56 after a long struggle with pancreatic cancer, was a man full of deep contradictions, a product of 1960s counterculture who went on to found what is now the world's most valuable technology company, Apple Inc. (AP Photo/Patrice Gilbert)

A customer looks at the book "Steve Jobs," by Walter Isaacson at a Costco store in Mountain View, Calif., Wednesday, Oct. 26, 2011. Jobs told Isaacson he wanted him to write his biography because he's good at getting people to talk. Jobs, it turns out, didn't need much prodding, secretive as he was about both his private life and the company he founded. "I just listened," said Isaacson, whose book, "Steve Jobs" went on sale Monday, Oct. 24, 2011. Jobs, who died Oct. 5 at the age of 56 after a long struggle with pancreatic cancer, was a man full of deep contradictions, a product of 1960s counterculture who went on to found what is now the world's most valuable technology company, Apple Inc. (AP Photo/Paul Sakuma)

The book "Steve Jobs," by Walter Isaacson is on display at a book shop in Menlo Park, Calif., Monday, Oct. 24, 2011. The depths of Jobs' antipathy toward Google leaps out of Walter Isaacson's authorized biography of Apple's co-founder. The book goes on sale Monday, less than three weeks after Jobs' long battle with pancreatic cancer culminated in his Oct. 5 death. (AP Photo/Paul Sakuma)

Copies of the book "Steve Jobs," by Walter Isaacson are piled high at a book shop in Menlo Park, Calif., Monday, Oct. 24, 2011. The depths of Jobs' antipathy toward Google leaps out of Walter Isaacson's authorized biography of Apple's co-founder. The book goes on sale Monday, less than three weeks after Jobs' long battle with pancreatic cancer culminated in his Oct. 5 death. (AP Photo/Paul Sakuma)

Copies of the book "Steve Jobs," by Walter Isaacson are piled high a book shop in Menlo Park, Calif., Monday, Oct. 24, 2011. The depths of Jobs' antipathy toward Google leaps out of Walter Isaacson's authorized biography of Apple's co-founder. The book goes on sale Monday, less than three weeks after Jobs' long battle with pancreatic cancer culminated in his Oct. 5 death. (AP Photo/Paul Sakuma)

NEW YORK (AP) ? Steve Jobs told Walter Isaacson he wanted him to write his biography because he's good at getting people to talk. Jobs, it turns out, didn't need much prodding, secretive as he was about both his private life and the company he founded.

"I just listened," said Isaacson, whose book, "Steve Jobs" (Simon & Schuster) went on sale Monday. Jobs, who died Oct. 5 at 56 after a long struggle with pancreatic cancer, was a man full of deep contradictions, a product of 1960s counterculture who went on to found what is now the world's most valuable technology company, Apple Inc.

In an interview with The Associated Press Wednesday, Isaacson said Jobs was a compelling storyteller with "fascinating stories." Sometimes, the author would hear him tell those tales two or three times, often with slight variations. But through more than 40 conversations with Jobs, as well as interviews with his family, close friends, co-workers and rivals, Isaacson painted a rich portrait of a complex, sometimes conflicting figure.

Isaacson began work on the book in 2009 after Jobs' wife, Laurene Powell, told him that if he was "ever going to do a book on Steve, you'd better do it now." It was just after Jobs had taken his second medical leave as CEO of Apple, in January of that year. His third leave, which began in January 2011, would be his final one.

"He was not sick through much of this process," Isaacson said, when asked about what it was like to be working on the book and speaking with Jobs' family while he was ill.

"We took long walks," he said. "Every evening, he would have dinner around the kitchen table with his wife and kids. He didn't go out socializing or to black-tie dinners. He didn't travel much. Even though he was focused on his work, he was always home for dinner."

Those who see Jobs as the iconic CEO first might be surprised to read about his devotion to his family. It wasn't always evident. As a young man, Jobs denied paternity of his first daughter, Lisa Brennan-Jobs, for years after Lisa was born in 1978. The two later reconciled.

Isaacson said he was most surprised by the intensity of Jobs' emotions.

"Sometimes I'd look up and there would be tears running down his cheek," Isaacson said.

Jobs told him he was always moved by "artistic purity." Sometimes, it was the design of a product, or even the creation of an advertisement that would move him to tears. Other times, it happened as he talked about a person who meant a lot to him. For his 20th wedding anniversary with Powell, Jobs wrote her a letter that he read to Isaacson from his iPhone. By the end, Isaacson said, he was crying uncontrollably.

"Years passed, kids came, good times, hard times, but never bad times," Jobs wrote in the note. "Our love and respect has endured and grown."

Those around Jobs referred to his ability to influence the perception of those around him as his "reality distortion field." Though on the surface it sounds similar, this was far more complex than someone who is lying or deluding himself. As Apple co-founder Steve Wozniak puts it in the book: "You realize that it can't be true, but he somehow makes it true."

The "reality distortion field" was Jobs' way of getting people to do what they thought was impossible, Isaacson said. An example was how he'd tell an engineer working on the Macintosh that he could save 10 seconds on the time the computer needed to boot up if he just wrote better code.

"And the guy would say 'no you can't,'" Isaacson said.

Jobs then asked the engineer if he could do it if it would save a life. And so the engineer did; he wrote better code and he shaved not 10 but 28 seconds off the Macintosh's boot-up time.

While writing the book, Isaacson said he came to understand the connection between Jobs' temperamental behavior and his artistic passion.

"I have a strong emotional respect for Steve," he said. "And it helped me put in perspective ... the tales of him being hard on people. Because I knew it was all in the context of getting people to do the impossible. Which he did."

Isaacson didn't spend time shadowing Jobs, though he did spend an afternoon at the design studio of Jony Ive, the chief designer at Apple who worked on the iPod, the iPhone and the iPad. It was Ive who came up with the idea of making the first iPod, including its headphones, pure white. In the afternoons, Isaacson said Jobs would walk around Ive's studio and touch all the new prototypes that were laid out there.

"He was a very tactile person," Isaacson said. "He loved to fondle the prototypes."

Isaacson spent a long afternoon in that studio and doing so "realized what a serene experience it was. Quiet, with new-age jazz playing softly. The leaves from the trees outside casting dancing silhouette shadows on the tinted windows. And even small products like power adapters being lined up for inspections."

Can Apple continue to thrive without Jobs?

"Yeah, I think that his great creation was not any one product but a company in which creativity was connected to great engineering," Isaacson said. "And that will survive at least while the current people who trained under Steve are there."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2011-10-26-Isaacson-Steve%20Jobs/id-1b0ee33f1ec74d4789501d21cc4345d1

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Compound found in common wart treatment shows promise as leukemia therapy

ScienceDaily (Oct. 26, 2011) ? A new potential leukemia therapy targets only cancer cells, while leaving healthy cells alone. Many current chemotherapy treatments affect cancer cells and healthy cells, causing significant side effects, such as fatigue, hair loss, nausea, anxiety and depression.

This research is being presented at the 2011 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in Washington, D.C., Oct. 23-27.

Leukemia is a cancer of the blood and bone marrow, the spongy center of bones where blood cells are formed. According to the Leukemia and Lymphoma Society, an estimated 43,050 people were diagnosed with leukemia in the U.S. in 2010.

Lead researcher and AAPS fellow, Peter A. Crooks, Ph.D., and his colleagues from the University of Arkansas for Medical Sciences have developed a potent compound that only impacts cancer cells, and starts killing them as early as four hours after treatment begins.

"This is one of the most potent and selective compounds I have ever seen during my more than 30-year career," said Crooks.

The molecules used to create this anti-leukemic agent are structurally similar to the compound found in many gout treatments and over-the-counter products used to treat warts, which also prevent cell growth. This agent is able to reach cancer cells before they mature, so catching the disease in its early stages will eradicate it quickly. This is especially vital for treating acute myeloid leukemia, which progresses rapidly without treatment.

"It's good to get excited in the early stages of research when you discover a treatment that could potentially be as outstanding as this," said Crooks. "However, the next phase is to test the treatment in animal models and pinpoint the most effective delivery method."

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The above story is reprinted from materials provided by American Association of Pharmaceutical Scientists.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/10/111026091233.htm

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The 9 Skills Needed to Be a Super-Connector

I know why I'm not a billionaire. Other than having the consistent self-sabotaging quality of destroying money in massive bonfires every time I sell a company, I also have a severe psychosocial disorder which makes me a horrible connector of people. Connecting people who can benefit each other is the most useful skill you can have on the entrepreneurial ladder of skills. When you help others make money by connecting them together, the world forces itself into the M?bius strip of success that brings the money right back to you times ten. Some billionaires are great at it. If I write Mark Cuban an email he responds in two seconds even though he doesn't even know me. He's a "Super Connector". I know quite a few talented super connectors and they will be very successful as they grow into future Mark Cubans

Source: http://feedproxy.google.com/~r/Techcrunch/~3/9J7vDyDQdq0/

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The Most Common Hiding Places for Workplace Passwords [Passwords]

When I was an IT admin, I had the pleasure of dealing often with people who would submit urgent service requests and then leave for the day, leaving their office empty and computer locked by the time I could get there to help. Fortunately, I was often able to fix their problem while they weren't there. Why? Their password was somewhere on their desk in one of these easy-to-find locations.

• Under the Keyboard. This is a pretty common one, and one of the first places to look if you need to find someone's password (or one of the first places to avoid if you need to jot down an often-used but difficult to remember password.) The worst offenders leave them on a post-it on their keyboard tray, or under the spot where their keyboard lives. Others attach the post-it to the underside of the keyboard, thinking it's better hidden there. In both cases, it's a sure bet that anything under the keyboard will have a password on it.
• Under the Phone. A surprising number of people still keep their passwords tacked to the underside of their desk phone or its receiver. The people who usually put their passwords here think they're being smart and stealthy, but in reality taping a yellow post-it note to the underside of your phone just screams "passwords here!"
• Under the Mouse Pad. This is another common hiding place for people who don't want to put their passwords under their keyboard. They'll usually slide a couple of sheets of paper under the mousepad with their usernames and passwords on it and refer to them when they forget, or update them when their password expires.
• On the Monitor. This one isn't so much a "hiding place," as it's one of those "security through obscurity" techniques that almost never work. Most often practiced by people who keep dozens of other post-its on their monitor, this technique is still easy to get around as soon as you have physical access to the person's computer. Besides, it's not too hard to glance through the post-its on the monitor and find the one that has "u: something/p: something else" on it.
• In the Top Drawer. Most people who work in open offices with short cubicles tend to lock their desk drawers, but colleagues I've worked with who had their own offices or had semi-isolated cubicles were almost always guilty of leaving their desk drawers unlocked. When I would visit their offices, the master list of their usernames and passwords were almost always in the top drawer, on a scrap of paper or the top of a thick stack of post-it notes, usually in plain view.
• Under the Desk. One of the most disturbingly common spots many officer workers hide their passwords is one of the easiest to find: right under their desk surface. Just sit down at their desk and put your hand directly under the desktop, and you'll often find yet another post-it note attached there. Most people who do this operate under the assumption that no one's ever under their desk to see or notice such a thing?except the IT admin or help desk tech they call when they've jostled the Ethernet cable loose from the back of their desktop.

This list isn't exhaustive: anyone who's spent time as a field technician or IT admin in an office will tell you that people often leave their passwords in strange places that are easier to find then the user ever hoped they would be.

In many offices, the most common hiding spots for post-it notes and paper scraps laden with login information depend on the office furniture and office layout. For example, if your cubicles have low cabinets right over most users' monitors, you can expect to find a few people keeping their passwords on the inside of those cabinets. I knew one person who put post-it notes on the bottom of their chair?she was livid when she arrived one morning to find a colleague had borrowed her chair for an impromptu meeting in her office next door.

If you keep your passwords in any of these places, stop now before it's too late. You may be making your IT admin's life a little easier when he or she drops by to fix your computer problems, but they know full well you're sacrificing your organization's security in the process. Now is a good time to give a service like LastPass, an app like 1Password, or one of these great alternatives a try, so you can remember one password and then mix up the passwords you use for other services. While you're at it, make sure you're using good, strong passwords.

Do you know an office worker that keeps their passwords on post-its or in notebooks on their desk? How do you keep your passwords safe from prying eyes without compromising their security? Share your tips in the comments. Photo by Juan Martinez.

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You can reach Alan Henry, the author of this post, at alan@lifehacker.com, or better yet, follow him on Twitter or Google+.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/AclgiDthVew/the-most-common-hiding-places-for-workplace-passwords

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Body weight, diet may be risk factors for non-Hodgkin lymphoma

ScienceDaily (Oct. 24, 2011) ? Body weight in young adulthood and diet appeared to be associated with the risk for non-Hodgkin lymphoma, according to results presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011.

"The causes of non-Hodgkin lymphoma (NHL) are poorly understood, and unfortunately, we don't know very much about specific ways to prevent or lower the risk for this disease," said Kimberly Bertrand, Sc.D., research fellow in the department of epidemiology at the Harvard School of Public Health.

In previous analyses of the Nurses' Health Study at 14 years of follow-up, lead researcher Shumin Zhang, M.D., Sc.D., and colleagues reported positive associations with NHL for trans fat intake and inverse associations for vegetable intake. To expand those findings, Bertrand and colleagues evaluated the association of obesity, specific types of dietary fats, and fruits and vegetables with risk for NHL.

Researchers analyzed questionnaire responses from 47,541 men followed for 22 years in the Health Professionals' Follow-Up Study and 91,227 women followed for 28 years in the Nurses' Health Study. Among the women, researchers confirmed 966 incident diagnoses of NHL through 2008, and among the men, they confirmed 566 cases through 2006.

"In analyses that controlled for age, race and other factors, we found that obesity in young adulthood (ages 18 to 21 years) was associated with risk for NHL later in life," Bertrand said. "Men who were obese (body mass index [BMI] equal to or greater than 30) [in young adulthood] had a 64 percent higher risk for NHL compared with men who were lean, while obese women had a 19 percent higher risk."

Current BMI was also associated with risk for NHL in men but not in women. Although total and specific dietary fats were not associated with NHL risk, findings also suggested that women who consumed the highest amounts of trans fat in their diets had a nonstatistically significant increased risk for NHL overall. "We observed that women who consumed at least four servings of vegetables per day, compared with those who consumed fewer than two servings per day, had a 16 percent lower risk for developing NHL," Bertrand said.

"The results from this study, if confirmed in other studies, suggest that body weight and dietary choices may be potentially modifiable risk factors for NHL," she said. Bertrand and colleagues also plan to investigate associations of obesity and dietary factors with common subtypes of NHL, to evaluate biomarkers of fatty acids related to NHL risk to obtain more information on the possible biological mechanism for these associations, and to investigate other dietary factors including red meat consumption and antioxidants.

The study was supported by the American Cancer Society with funds to senior researcher, Brenda Birmann, M.Sc., Sc.D. (RSG-11-020-01-CNE), and by the National Institutes of Health (CA055075 and CA87969). Bertrand was supported by a training grant from the National Cancer Institute (R25 CA098566).

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Source: http://www.sciencedaily.com/releases/2011/10/111024084712.htm

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Unraveling the mysteries of the natural killer within us

Monday, October 24, 2011

Scientists have discovered more about the intricacies of the immune system in a breakthrough that may help combat viral infections such as HIV.

Co-led by Professor Jamie Rossjohn of Monash University and Associate Professor Andrew Brooks from University of Melbourne, an international team of scientists have discovered more about the critical role Natural Killer cells play in the body's innate immune response.

The findings were published today in Nature.

Natural Killer cells are a unique type of white blood cell important in early immune responses to tumours and viruses. Unlike most cells of the immune system that are activated by molecules found on the pathogen or tumour, Natural Killer cells are shut down by a group of proteins found on healthy cells.

These de-activating proteins, known as Human Leukocyte Antigens or HLA molecules are absent in many tumours and cells infected with viruses, leaving them open to attack by the Natural Killer cells.

Natural Killer cells recognise the HLA molecules using an inbuilt surveillance system called "Killer cell immunoglobulin-like receptors" (KIR).

Using the Australian Synchrotron, the team determined the three dimensional shape of one of these key KIR proteins, termed KIR3DL1, which binds to a particular HLA molecule.

This pairing is known to play a role in limiting viral replication in people with HIV, slowing the progression of the disease to AIDS.

Professor Rossjohn said that better understanding the structure of KIR proteins may help to develop approaches to better utilise Natural Killer cells to combat viral infection.

"It is only possible to detect proteins, such as KIRs, using extremely high-end equipment. The use of the platform technologies at Monash and the Australian Synchrotron was absolutely essential to this project's success," Professor Rossjohn said.

Professor Brooks said the researchers would use these findings to investigate other KIR molecules.

"Since KIR3DL1 is only a single member of a much larger family of receptors, the study provides key insight into how Natural Killer cells utilise other members of this important family of receptors to recognise virus-infected cells and tumours." Professor Brooks said.

###

Monash University: http://www.monash.edu.au

Thanks to Monash University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/114550/Unraveling_the_mysteries_of_the_natural_killer_within_us

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Why you should start investing in the stock market

There are several reasons to start investing in the stock market.

1. Compounding
2. Historical Returns
3. Efficient Taxation

Compounding refers to how a an investment will progressively earn greater and greater returns the longer it is invested. For example, let?s say you invest $10,000 in the stock market and average a 10% return annually. In year 1, you will earn $100 or 10%, but in year two you will earn $110 or 11% on your original $1,000 and in year 25 you would earn approximately $985, almost 100% of your original investment. The longer your money is compounding the greater your returns will be asusming you can maintain the percentage return.

Historical returns for the stock market have over the long run outperformed other types of investments such as bonds, preferred shares, GICs and money market investments. This is even more true today with interest bearing investments paying such low rates. The rate of a 5 year GIC is currently about 1.85%, which is not even keeping up with inflation in Canada, which is currently at 3.1%

Efficient Taxation refers to the way that investments in the stock market are taxed less than other investments. When you invest in an interest bearing investment such as a bond or GIC, the interest is treated as regular income and you will have to pay income tax at your current marginal rate of tax. When you invest in the stock market, you can earn capital gains or dividend income both of which are taxed more favourably than interest income. Capital gains arise when you sell shares for more than you paid for them and they receive a 50% tax break. If you earn $10,000 from a stock investment only $5,000 of it will be taxed, this mean that the most you will ever pay is 23.2% tax if you were in the highest tax bracket. Dividend income receives favourable tax treatment as well. When dividend income is received the amount reported as income would be grossed up by 45%, however,a 19% dividend tax credit significantly reduces tax you will pay on them. In fact, Canadians with no other sources of income can receive over $65,000 in dividend income tax free when the basic personal amount and dividend tax credits are applied.

The above examples are just a few of the reasons why you should start investing in the stock market and there are way to safely do so if you take the time to properly educate yourself.

About the Author

Jason Inget, CA
Jason Inget is the founder of http://www.investmenttutor.ca an educational company that provides one on one investment tutoring sessions to those looking to start investing in the stock market.

Article source: http://goarticles.com/article/Why-you-should-start-investing-in-the-stock-market/5542329/

Source: http://www.articles-digest.com/why-you-should-start-investing-in-the-stock-market/

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Pope names 3 new saints, man disrupts Mass (AP)

VATICAN CITY ? Pope Benedict XVI has created three new saints for the Catholic Church during a Mass in St. Peter's Square that was disrupted by a man who climbed up to the colonnade surrounding the square and burned a book.

Vatican gendarmes, a bishop and the pope's own bodyguard eventually talked the man down from the upper reaches of the colonnade after he shouted, "Pope, where is Christ?" in English.

The disruption came toward the end of a two-hour Mass Sunday to canonize three 19th-century founders of religious orders: Italian bishop and missionary Monsignor Guido Maria Conforti, Spanish nun Sister Bonifacia Rodriguez de Castro and an Italian priest who worked with the poor, the Rev. Luigi Guanella.

Benedict appeared unfazed by the disruption.

Source: http://us.rd.yahoo.com/dailynews/rss/religion/*http%3A//news.yahoo.com/s/ap/20111023/ap_on_re_eu/eu_vatican_saints

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Gov. Perdue visits NC-linked schools during China visit

By:?News 14 Carolina Staff

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SHANGHAI ? Governor Perdue's trade mission to Asia this week took on a taste of home feel.

Perdue paid visits to two schools linked to North Carolina during her travels to the Far East. She spoke at a university in Shanghai to celebrate the 30-year relationship they have with UNC.

Gov. Perdue also visited a Chinese campus named Duke Kunshan University that is set to open in 2013. China is the state's second largest trading partner, Japan is the fourth largest.

This is Gov. Perdue's second trip to the area since she took office in 2009. The governor heads to Japan this weekend before heading home.

Source: http://sandhills.news14.com/content/top_stories/648534/gov--perdue-visits-nc-linked-schools-during-china-visit

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The Bay Citizen: Voracious Mice Scramble Food Chain on California?s Farallon Islands

[unable to retrieve full-text content]A plague of mice has attracted migrating California owls, forcing the government to consider eradication methods.

Source: http://feeds.nytimes.com/click.phdo?i=295109762b966c4303c3fe12a58f5c36

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